NARS1

Clinical Characteristics for Families

Other features of the condition include difficulty coordinating movements (ataxia), speech problems, and a decline in intellectual function.

Additional features include:

Central Nervous System
•    Global developmental delay, moderate to profound
•    Impaired intellectual development, moderate to profound
•    Neurodegeneration
•    Speech and language delay
•    Absent speech
•    Delayed walking
•    Ataxic gait
•    Abnormal gait
•    Broad-based gait
•    Speech and language delay
•    Unsteady gait
•    Foot drop
•    Spasticity (in some patients)
•    Seizures (myoclonic or generalized tonic-clonic) (in some patients)
•    Nonspecific findings seen on brain imaging (in some patients)
•    Cerebral atrophy
•    Thin corpus callosum
•    Delayed myelination
•    Decreased white matter volume
•    Hypertonia
•    Hyperreflexia
•    Tremor
•    Dysarthria

Peripheral Nervous System
•    Demyelinating sensorimotor (peripheral) neuropathy
•    Impaired distal sensation
•    Hyporeflexia
•    Distal sensory loss

Behavioral Psychiatric Manifestations
•    Stereotypic behavior