Currently, there is no known cure for an SMG8-related disorder. Treatment of the manifestations, symptom management, and supportive care are recommended.

While there is no cure to this disorder, each of its manifestations can be managed by the appropriate specialty such that a multidisciplinary approach to coordinate the potentially complex management plan for these children is necessary. For example, early intervention programs are typically required to maximize the developmental potential of these children. A cardiologist may be involved in the case of a congenital heart disease. Ophthalmology evaluation is warranted, and long term follow up may be required if eye abnormalities are present. Depending on whether genitourinary malformations are present, urologic intervention may also be required.