Currently, there is no known cure for SLC25A22-related disorders. Treatment of the manifestations, symptom management and supportive care are recommended and can be managed by the appropriate specialty.

All patients with SLC25A22-related disorders must undergo in-depth neurological examination and developmental evaluation. Visual and auditory evoked potentials should be analyzed. Video EEG monitoring, including sleep EEG monitoring, and brain MRI imaging should be performed.