SHOX2

Publications

Bapat A et al. Genomic basis of atrial fibrillation. Heart. 2018;104(3):201-206. PMID: 28893835.

Blaschke RJ et al. Targeted mutation reveals essential functions of the homeodomain transcription factor Shox2 in sinoatrial and pacemaking development. Circulation. 2007;115(14)1830-1838. PMID: 17372176.

Chugh SS et al. Global burden of atrial fibrillation in developed and developing nations. Glob Heart. 2014;9(1):113-9. PMID: 25432121.

Delaney JA et al. Hospital and clinical care costs associated with atrial fibrillation for Medicare beneficiaries in the Cardiovascular Health Study and the Framingham Heart Study. SAGE Open Med. 2018;6:2050312118759444. PMID: 29511541.

Fatkin D et al. Genetics of Atrial Fibrillation: State of the Art in 2017. Heart Lung Circ. 2017;26(9):894-901. PMID: 28601532.

Hoffmann S et al. Coding and non-coding variants in the SHOX2 gene in patients with early-onset atrial fibrillation. Basic Res. Cardiol.2016, 111(3):36. PMID: 27138930.

Hoffmann S et al. Comparative expression analysis of Shox2-deficient embryonic stem cell-derived sinoatrial node-like cells. Stem Cell Res. 2017;21:51-57. PMID: 28390247.

Hoffmann S et al. Functional characterization of rare variants in the SHOX2 Gene identified in sinus node dysfunction and atrial fibrillation. Front Genet. 2019, 10:648. PMID: 31354791.

Hoffmann S et al. Islet1 is a direct transcriptional target of the homeodomain transcription factor Shox2 and rescues the Shox2-mediated bradycardia. Basic Res Cardiol. 2013;108(2):339. PMID: 23455426.

Hoffmann S et al. Network-driven discovery yields new insight into Shox2-dependent cardiac rhythm control. BBA – Gene Regul Mech. 2021;1864(4-5):194702. PMID: 33706013.

Kirchhof P et al. [2016 ESC Guidelines for the management of atrial fibrillation developed in collaboration with EACTS.] Kardiol Pol. 2016;74(12):1359-1469. PMID: 28009037.

Li N et al. A SHOX2 loss-of-function mutation underlying familial atrial fibrillation. Int J Med Sci. 2018;15(13):1564-157. PMID: 30443179.

Li N et al. Signaling pathways and clinical application of RASSF1A and SHOX2 in lung cancer. J Cancer Res Clin Oncol. 2020;146(6):1379-1393. PMID: 32266538.

Lippi G et al. Global epidemiology of atrial fibrillation: An increasing epidemic and public health challenge. Int J Stroke. 2020;16(2):217-221. PMID: 31955707.

Puskaric S et al. Shox2 mediates Tbx5 activity by regulating Bmp4 in the pacemaker region of the developing heart. Hum Mol Genet. 2010;19(23):4625-4633. PMID: 20858598.

Roselli C et al. Multi-ethnic genome-wide association study for atrial fibrillation. Nat Genet. 2018;50(9):1225-1233. PMID: 29892015.

Roselli C et al. Genetics of Atrial Fibrillation in 2020: GWAS, Genome Sequencing, Polygenic Risk, and Beyond. Circ Res. 2020;127(1):21-33. PMID: 32716721.

Schmidt B et al. SHOX2 DNA methylation is a biomarker for the diagnosis of lung cancer based on bronchial aspirates. BMC Cancer. 2010;10:600. PMID: 21047392.

Schmitteckert S et al. Murine transgenic embryonic stem cell lines for the investigation of sinoatrial node-related molecular pathways. Stem Cell Res. 2017;25:278-282. PMID: 29246574.

Schneider KU et al. Correlation of SHOX2 gene amplification and DNA methylation in lung cancer tumors. BMC Cancer. 2011;11:102. PMID: 21426551.

Song L et al. Diagnosis of Lung Cancer by SHOX2 Gene Methylation Assay. Mol Diagn Ther. 2015;19(3):159-167. PMID: 26014676.

Sumer SA el al. Precise Correction of Heterozygous SHOX2 Mutations in hiPSCs Derived from Patients with Atrial Fibrillation via Genome Editing and Sib Selection. Stem Cell Reports. 2020;15(4):999-1013. PMID: 32976766.

de Vos L et al. Treatment Response Monitoring in Patients with Advanced Malignancies Using Cell-Free SHOX2 and SEPT9 DNA Methylation in Blood: An Observational Prospective Study. J Mol Diagn. 2020;22(7):920-933. PMID: 32361006.