CLDN11

Clinical Characteristics for Families

HLD22 has been associated with the following health conditions:
•    Global developmental delay
    o    mildly impaired intellectual development
    o    marked motor impairment with limited or no ability to walk
    o    delay in speech development with dysarthria (articulation problems due to challenges with muscle control)
•    Neurologic exam may show limb spasticity, weakness, or increased reflexes
•    Vision problems may include far-sightedness, astigmatism and involuntary eye movements
•    Brain imaging may show changes in myelination patterns